The two England stars could go head-to-head for the first time since Walker’s big-money switch to Manchester City over the summer when Spurs travel to the Etihad Stadium.
City will be chasing an incredible 16th successive Premier League win, while Spurs are looking to continue their impressive run of form after a disastrous November for Mauricio Pochettino’s men.
And Rose is insisting that friendships will be put on hold until after the game.
“Of course, it will be nice to see him and play against him if I’m selected,” the left-back told ESPN.
“He’s the enemy this weekend. There’ll be no pleasantries until after the game.”
Rose, meanwhile, has found it difficult to reclaim his starting spot following his return from a long-term injury and he upset many Spurs fans in August when he criticised the club’s wage structure.
He heads to The Etihad hoping to beat out Ben Davies to the left-back spot for the game, but admitted he is not jealous of how Walker has flourished under City boss pep Guardiola.
“There’s no envy. He fully deserved his move,” the 27-year-old added.
“Over the last two to three years he has been the best right-back in the league. His assists and performances prove that.
“He’s got what he deserves and I wish him the best of luck in every game that he plays, apart from when he plays against us.”